SUMMARY
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STEPS TO REPRODUCE
1. have a canvas open & use the keyboard command "Command+" to zoom in. (I am using the Photoshop key command presets provided by the Krita program)
2. 
3. 

OBSERVED RESULT
after pressing the keyboard short cut of "command+" to zoom in other keyboard shortcuts like the "pan tool" =spacebar, "color selector"=command & magic mouse touch pad (used to move the canvas around like the pan tool) no longer work. There maybe other commands that aren't working but those are key ones that I use & have noticed.


EXPECTED RESULT
To regain the function of the keyboard short cuts clicking one of the buttons on the tools menu starts the shortcuts working until "command+" is pressed again. I use "Command+" to zoom all the time as well as the pan tool short cut, color picker short cut so it really does effect my usage of the product. I would imagine that the majority of your customers use those short cuts too. This problem was also in 5.0.5.

SOFTWARE/OS VERSIONS
Windows: 
macOS: 12.3.1
Linux/KDE Plasma: 
(available in About System)
KDE Plasma Version: 
KDE Frameworks Version: 
Qt Version: 

ADDITIONAL INFORMATION: Since selecting a tool bar button with the cursor fixed the problem I thought changing tools with the keyboard cause the malfunctioning shortcuts to work again. I tried several different keyboard short cuts like "C" crop or "G" gradient & then switch back to the brush tool but that didn't fix the problem though pressing the short cut key did change tools.