SUMMARY

I have several VMs setup (Fedora 35, Win10, ...) and for all I encounter the issue that the VM stops reacting to mouse or keyboard inputs after some time(?) or under certain conditions, such as when the VM becomes fullscreen and is transformed back to maximized window.

If this bug happens, the window itself can still be dragged and (host ctrl key + F) can be send to make it go/exit full screen and also Alt+F4 can still be send to the window, making VirtualBox display its "Shutdown VM Options" dialog, which cannot be used by the mouse, but at least with the keyboard.

However, the virtual machine's toolbar doesn't react anymore and the VM itself cannot be used.
Interestingly it's not completely frozen, since if `Meta` is hit, both KDE Plasma's kickoff as well as the VM's start menu open.

Under X11 everything works fine and I haven't experienced this issue yet. 

SOFTWARE/OS VERSIONS
Operating System: Fedora Linux 35
KDE Plasma Version: 5.24.3
KDE Frameworks Version: 5.91.0
Qt Version: 5.15.2
Kernel Version: 5.16.18-200.fc35.x86_64 (64-bit)
Graphics Platform: Wayland
Processors: 16 × AMD Ryzen 7 5700G with Radeon Graphics
Graphics Processor: AMD RENOIR

ADDITIONAL INFORMATION
VirtualBox: 6.1.32
KSM and AMD SRV
VBoxSVGA