SUMMARY
Two configuration items have inverted logic. When checked they do the opposite of what they say:

Under Spectacle->Configuration->General->After taking a screenshot, two items labeled "Copy image to clipboard" and "Autosave the image to the default location" only do as they say when they are unchecked. When checked the program does not do what they say, but when unchecked things work. This seems impractical and confusing. In order to minimize Spectacle from being confusing I'm reporting this opposite than expected behavior.


STEPS TO REPRODUCE
1. Under Configuration->General->After taking a screenshot, check both "Copy image to clipboard & "Autosave the image to the default location"
2. Close the program
3. Use the rectangle shortcut key to capture a region SHIFT+Prt Scr
4. Check default location for saved file and there is none.
5. Uncheck the settings previously checked & repeat screenshot to see image captured and saved correctly

OBSERVED RESULT
No saved screenshot to default location with appropriate setting checked

EXPECTED RESULT
Image expected to be saved

SOFTWARE/OS VERSIONS
Windows: 
macOS: 
Linux/KDE Plasma: 
(available in About System)
KDE Plasma Version: 
KDE Frameworks Version: 
Qt Version: 

ADDITIONAL INFORMATION
I noticed that screenshot behavior is ok if the program is on the desktop while taking a screenshot. However while the program is not on the desktop and using hotkeys to capture a region the settings for "When Spectacle is Running" seem to affect the program inversely even when the program is not running. There may be more than a bug here; quite possibly a rework of the configuration logic may be needed.