Tested with Valgrind 3.16.1 STEPS TO REPRODUCE 1. Execute a program that uses the CLFLUSHOPT instruction OBSERVED RESULT vex amd64->IR: unhandled instruction bytes: 0x66 0xF 0xAE 0x3C 0x25 0xE0 0x1 0x0 0x70 0xC3 vex amd64->IR: REX=0 REX.W=0 REX.R=0 REX.X=0 REX.B=0 vex amd64->IR: VEX=0 VEX.L=0 VEX.nVVVV=0x0 ESC=0F vex amd64->IR: PFX.66=1 PFX.F2=0 PFX.F3=0
For reference, this is the corresponding disassembly: 1531c: 66 0f ae 3c 25 e0 01 clflushopt 0x700001e0 15323: 00 70
Note that you should check first with the cpuid feature flag CLFLUSHOPT whether the instruction is supported or not (valgrind doesn't set it).
*** Bug 456948 has been marked as a duplicate of this bug. ***