When painting, there's a rare bug, that will cause to certain brush setting get stuck on all the brushes. It means if I change that one setting on a brush, it will apply for every brush and reload button won't work for it. This setting can be rotation, texture, brush tip or other that can be changed in the brush editor. Only way to revert it is restarting program. How to reproduce: I don't know what exactly causes this bug, it seems to be random. To try to reproduce this bug, work with brushes, use multiple brushes and change their settings often. Have "Temporary save tweaks to presets" setting turned on.
Deevad has complained about this issue, too. I haven't seen it myself, but I seldom use Krita for longer than an hour or so, and it seems that it gets worse the longer the session takes.