On Fedora rawhide ppc64: $ valgrind /usr/bin/python2 setup.py build_sphinx --offline ==18850== Memcheck, a memory error detector ==18850== Copyright (C) 2002-2015, and GNU GPL'd, by Julian Seward et al. ==18850== Using Valgrind-3.12.0 and LibVEX; rerun with -h for copyright info ==18850== Command: /usr/bin/python2 setup.py build_sphinx --offline ==18850== running build_sphinx running build running build_py running pre_hook from astropy._erfa.setup_package for build_py command running pre_hook from astropy.modeling.setup_package for build_py command WARNING: The autogenerated wrappers in astropy.modeling._projections seem to be older than the source templates used to create them. Because this is a release version we will use them anyway, but this might be a sign of some sort of version mismatch or other tampering. Or it might just mean you moved some files around or otherwise accidentally changed timestamps. running build_ext --18850-- WARNING: unhandled ppc64be-linux syscall: 251 --18850-- You may be able to write your own handler. --18850-- Read the file README_MISSING_SYSCALL_OR_IOCTL. --18850-- Nevertheless we consider this a bug. Please report --18850-- it at http://valgrind.org/support/bug_reports.html. error: [Errno 38] Function not implemented: 'astropy/_compiler.c'