After setting konqueror to handle ed2k links (I created ed2k.protocol in ~/.kde/share/kde4/services/) these still do not work.
After some testing I found the problem to be the pipe "|" in the link.
I created an html page with this:

<a href="ed2k://|file|name.txt|1000000|000000000000000000000000000000|/">test</a><br/>
<a href="ed2k:///|file|name.txt|1000000|000000000000000000000000000000|/">test</a><br/>
<a href="ed2k://test/|file|name.txt|1000000|000000000000000000000000000000|/">test</a><br/>

where the first is a valid ed2k, the others are modified by adding an extra / and an extra /test

When I click the first link nothing happens, when I click the second or the third the ed2k manager is called (but it tells that the link is not valid).

The problem is with the | that are in the part than would be the domain name in a regular http link.

I know that this char is not allowed in domain names, but the way konqueror handles them breaks ed2k links.
The same problem occur with rekonq.

Reproducible: Always

Steps to Reproduce:
1. Set up konqueror to handle ed2k links
2. Click on a ed2k link

Actual Results:  
nothing appens

Expected Results:  
ed2k link manager called