When using valgrind with a simple program on a Power-QUICC-III, the program is 
direct stopped due to 

disInstr(ppc): unhandled instruction: 0x7D295F1E
                 primary 31(0x1F), secondary 1822(0x71E)
==00:00:00:00.362 31610== valgrind: Unrecognised instruction at address 
0x4004E10.

...

==00:00:00:00.362 31610== Process terminating with default action of signal 4 
(SIGILL): dumping core
==00:00:00:00.363 31610==  Illegal opcode at address 0x4004E10
==00:00:00:00.363 31610==    at 0x4004E10: _dl_start (do-rel.h:79)
==00:00:00:00.363 31610==    by 0x4010D08: _start (dl-start.S:39)
==00:00:00:00.365 31610== 

It appears to be the new "isel" instruction, which is newly introduced for the 
e500 core of this PowerQuick. The ppc objdump of the _dl_start at ld-2.3.3.so
also seems to be having some trouble with this instruction:


    4dfc:       80 0a 00 04     lwz     r0,4(r10)
    4e00:       54 09 08 3c     rlwinm  r9,r0,1,0,30
    4e04:       7d 29 02 14     add     r9,r9,r0
    4e08:       55 29 10 3a     rlwinm  r9,r9,2,0,29
    4e0c:       7f 89 58 40     cmplw   cr7,r9,r11
    4e10:       7d 29 5f 1e     .long 0x7d295f1e
    4e14:       7d 0b 43 78     mr      r11,r8
    4e18:       7f e8 4a 14     add     r31,r8,r9
    4e1c:       7f 88 f8 40     cmplw   cr7,r8,r31
    4e20:       40 9c 00 20     bge-    cr7,4e40 <_dl_start+0x338>
    4e24:       80 0b 00 08     lwz     r0,8(r11)
    4e28:       81 2b 00 00     lwz     r9,0(r11)

cat /proc/cpuinfo 
processor       : 0
cpu             : e500
revision        : 2.0 (pvr 8020 0020)
bogomips        : 524.28
chipset         : 8555E
Vendor          : Motorola SPS
Machine         : CPLAB PQ3MC1
bus freq        : 528.000000 MHz
PVR             : 0x80200020
SVR             : 0x80790011
PLL setting     : 0x4
Memory          : 2040 MB


To support the "isel" instruction, I expect changes to be made at
VEX/priv/guest-ppc/toIR.c:
line 9263:

      /* Integer Load Instructions */
      case 0x057: case 0x077: case 0x157: // lbzx,  lbzux, lhax
      case 0x177: case 0x117: case 0x137: // lhaux, lhzx,  lhzux
      case 0x017: case 0x037:             // lwzx,  lwzux
      case 0x00F: case 0x02F: case 0x04F: // <<<  isel: isellt, iselgt, iseleq
         if (dis_int_load( theInstr )) goto decode_success;
         goto decode_failure;

and function dis_int_load. However how the changes look there, I do not know.

I cannot say if other changes are necessary to support this version of the 
PowerQuick. The "isel" is at least a start.